Arimidex (Anastrozole) 1 mg Tablet

Package:

• 28 tablets of 1 mg each.

Indications:

• Used in the treatment of hormone receptor-positive, postmenopausal women with early-stage breast cancer who have progressed on tamoxifen or other antiestrogens.
• Also used in the treatment of advanced breast cancer in postmenopausal women.

Contraindications:

• Contraindicated in pregnancy and lactation.
• Contraindicated in patients with severe renal impairment.
• Contraindicated in patients with moderate or severe hepatic impairment.
• Contraindicated in patients with known hypersensitivity to anastrozole.
• Estrogen-containing therapy should not be used concomitantly, as it will antagonize the pharmacological action of anastrozole.

Warnings:

• At the start of treatment, there may be a deterioration in activities requiring concentration, such as driving.
• Does not reduce the patient's ability to drive or operate machinery. However, caution is advised if such symptoms occur, as astenia and somnolence have been reported with anastrozole use.

Side Effects:

• Hot flashes, vaginal dryness, hair loss, anorexia, nausea, vomiting, diarrhea, asthenia, somnolence, headache, skin rash, and vaginal bleeding (rarely in the first few weeks) may occur.
• May cause a slight increase in total cholesterol levels.

Drug Interactions:

• Estrogen-containing therapy should not be used concomitantly, as it will antagonize the pharmacological action of anastrozole.

Dosage Recommendations:

• 1 mg orally once daily in adults, including the elderly.
• For early-stage breast cancer, 5 years of treatment is currently recommended.
• The optimal duration of treatment has not yet been established.